Mouse Anti-Fruit fly raskol Antibody (MO-AB-03016W)
Cat: MO-AB-03016W
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Specifications
- Application Information
- Target
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Fruit fly (Drosophila melanogaster) |
Clone | MO03016W |
Specificity | This antibody binds to Fruit fly raskol. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | GTPase-activating protein, which acts as a negative regulator for some members of the Ras family. Probably decreases their signaling activity by stimulating their intrinsic GTPase activity, thereby lowering the levels of the GTP-bound active form. Functions with DE-cadherin (shg) to promote embryonic border cell (BC) migration and adhesion by regulating the distribution of actin protrusions in BCs (PubMed:30763317). Promotes shg-mediated adhesion at the BC interfaces and likely maintains BC cluster adhesion during BC detachment from the follicular epithelium and subsequent BC migration (PubMed:30763317). Also required for restricting the development of actin-rich protrusions to the front of migrating BC clusters thus ensuring unidirectional BC migration (PubMed:30763317). Possibly functions by suppressing Rac1 signaling in non-leading BCs, thus limiting its activity to leading BCs where it initiates localized actin cytoskeleton remodeling to produce the polarized protrusions (PubMed:30763317). (From uniprot, under CC BY 4.0) |
Product Overview | Mouse Anti-Fruit fly raskol Antibody is a mouse antibody against raskol. It can be used for raskol detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
Alternative Names | CG42684, isoform I; raskol |
UniProt ID | X2JFL7 |
Protein Refseq | The length of the protein is 2016 amino acids long. The sequence is show below: MLQAASSTTTAPVGNTADTGNSESPIIATPEEKSQRRRSTFYVPLVIEDEEETKKDTPADHLVQKSSSNTSLSSNSNSLTNSETKSSKSYSLRKSSSVKSGVAKVSALFERKTPSKMSPPCGFNWSISGSENTAQYSDTDDDEENSTEARHREQLLKTLPSGNNNSTTASPSKLKRYGIVLNVISLNGSDNEQSSLGSNGSSMPSMPSMPNGQNIPNAAAPRTHFNEENDIVLATPPPPKQQALSAAHESNDYDDDSEISRMQTNTSTPIKLMKSRSRTNILAVPLPSVERGLATTNTTPNNNNINGNSNGSTSNTTTTTTTTTLITLRAKSKTLPQNLSPSVVLREAAALDELEKKREKYQEKQEKREKLQEKQRQLFGGSTASQIAGSSPYKLQNSCSATSILTHSFPPKNLFLLKSTPKLSTDIAAATPPNTSAICSPPKKSLSFIRRAHSTKVARSNSLLKPNQAGILGSGSGSNGLGVHQGVMQGALSISCAGDNSSNNGSWGKHFYQPYDVCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENETTATADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVTKLERTKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSISTNPSPSQSSSPVESQLKAAMGSHNAPLAFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSLSGGSSSSTSASASTSNLGKSGGSSAYGRLNGPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQHPHQQQQNPMQQQQQRERDQEHKQYAGSVAGSVGSATSAAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDSFFQSSCRLITMEEELRREQLKMSLALSHKQRVIEEQGQQIAALDAANSRLLSALTALRQRYETQQQQQQHQAPPKTQKPQ. |
For Research Use Only | Not For Clinical Use.
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