Rabbit Anti-GAD2 Antibody (MO-DKB-00628W)


Cat: MO-DKB-00628W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Pig (Sus scrofa), Bovine (Bos taurus), Dog (Canis lupus familiaris), Rhesus (Macaca mulatta)
ImmunogenA recombinant protein containing the sequence in the C-terminal region of human GAD65.
EpitopeThe epitope is in the C-terminal of GAD2.
FormatLiquid or Lyophilized
BufferPBS, pH7, 20% Glycerol
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurityAffinity purified
Cellular LocalizationCytoplasm, cytosol, Cytoplasmic vesicle, Cell junction, synapse, presynaptic cell membrane, Golgi apparatus membrane

Application Information

ApplicationWB, IF, IHC, IHC-P
Application NotesWestern Blot 1:500-1:3000
Immunocytochemistry/Immunofluorescence 1:100-1:1000
Immunohistochemistry 1:100-1:1000
Immunohistochemistry-Paraffin 1:100-1:1000

Target

IntroductionThis gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Product OverviewThis product is a Rabbit antibody against the C-terminal of the GAD2. It can be used for GAD2 detection in Western Blot, Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin.
Alternative NamesGlutamate Decarboxylase 2; Glutamate Decarboxylase 2 (Pancreatic Islets And Brain, 65kDa); Glutamate Decarboxylase 65 KDa Isoform; 5 KDa Glutamic Acid Decarboxylase; EC 4.1.1.15; GAD-65;
Gene ID2572
UniProt IDQ05329
For Research Use Only | Not For Clinical Use.
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