Mouse Anti-Guinea pig ERG Antibody (MO-AB-41622W)


Cat: MO-AB-41622W
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityGuinea pig (Cavia porcellus)
CloneMO41622W
SpecificityThis antibody binds to Guinea pig ERG.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.
Product OverviewMouse Anti-Guinea pig ERG Antibody is a mouse antibody against ERG. It can be used for ERG detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesPotassium voltage-gated channel subfamily H member 2; ERG
UniProt IDH0VA82
Protein RefseqThe length of the protein is484 amino acids long.
The sequence is show below: FQTTGEKKAKIVEEALSVVSEDQSLFECAYGTPHLAKTEMTASSSGDYGQTSKMSPRVPQQDWLSQPPTRVTIKMECHPSQVNGSRNSPDECSVAKGGKMVSSPDTVGVNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYSLPDVDILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLREIPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPGPQSKAIQPSPSAVSKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHTHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTAGIYPNTRLPASHMPSHLGTYY.
For Research Use Only | Not For Clinical Use.
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