Mouse Anti-Hmgcr Antibody (CBMOAB-20619FYA)


Cat: CBMOAB-20619FYA
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Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-20619FYA Monoclonal Fruit fly (Drosophila melanogaster), Cat (Felis catus), Cattle (Bos taurus), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Elephant (Loxodonta africana), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Guinea pig (Cavia porcellus), Horse (Equus caballus), Mallard (Anas platyrhynchos), Marmoset, Pig (Sus scrofa), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta), Sheep (Ovis aries) WB, ELISA MO20619FYA 100 µg
CBMOAB-44656FYA Monoclonal Rhesus (Macaca mulatta) WB, ELISA MO44656FYA 100 µg
MO-AB-00628L Monoclonal Elephant (Loxodonta africana) WB, ELISA MO00628L 100 µg
MO-AB-02299Y Monoclonal Chicken (Gallus gallus) WB, ELISA MO02299Y 100 µg
MO-AB-04281H Monoclonal Frog (Xenopus laevis) WB, ELISA MO04281C 100 µg
MO-AB-08369Y Monoclonal Rabbit (Oryctolagus cuniculus) WB, ELISA MO08369Y 100 µg
MO-AB-08741W Monoclonal Cat (Felis catus) WB, ELISA MO08741W 100 µg
MO-AB-13708R Monoclonal Cattle (Bos taurus) WB, ELISA MO13708R 100 µg
MO-AB-15656Y Monoclonal Sheep (Ovis aries) WB, ELISA MO15656Y 100 µg
MO-AB-20312W Monoclonal Chimpanzee (Pan troglodytes) WB, ELISA MO20312W 100 µg
MO-AB-23282H Monoclonal Mallard (Anas platyrhynchos) WB, ELISA MO23282C 100 µg
MO-AB-26347R Monoclonal Pig (Sus scrofa) WB, ELISA MO26347R 100 µg
MO-AB-31133W Monoclonal Dog (Canis lupus familiaris) WB, ELISA MO31133W 100 µg
MO-AB-34896W Monoclonal Ferret (Mustela Putorius Furo) WB, ELISA MO34896W 100 µg
MO-AB-41807W Monoclonal Guinea pig (Cavia porcellus) WB, ELISA MO41807W 100 µg
MO-AB-45040W Monoclonal Horse (Equus caballus) WB, ELISA MO45040W 100 µg
MO-AB-56824W Monoclonal Marmoset WB, ELISA MO56824W 100 µg

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFruit fly (Drosophila melanogaster), Cat (Felis catus), Cattle (Bos taurus), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Elephant (Loxodonta africana), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Guinea pig (Cavia porcellus), Horse (Equus caballus), Mallard (Anas platyrhynchos), Marmoset, Pig (Sus scrofa), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta), Sheep (Ovis aries)
CloneMO20619FYA
SpecificityThis antibody binds to fruit fly Hmgcr.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationPeroxisome; Endoplasmic reticulum; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionHMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product OverviewMouse Anti-D. melanogaster Hmgcr Antibody is a mouse antibody against Hmgcr. It can be used for Hmgcr detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34; Hmgcr; HmG-CoAR
UniProt IDP14773
Protein RefseqThe length of the protein is 920 amino acids long.
The sequence is show below: MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDKNNTLDASSGLGTATASAAAAGGSGSGAGSGASGTIPPSSMGGSATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTAVLYCYYQFCSLHRLGSKYVLGIAGLFTVFSSFIFTTAIIKFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSGSNQAEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQRLEVLCMFAVLSVLVNYVVFMTFYPACLSLIFDLSRSGVDMSVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTGLMAVHIYSRVAFSGSDYDAVDKTLTPTLSLNVSNNRTESGEIADIIIKWLTMSADHIVISIVLIALVVKFICFDNRDPLPDQLRQSGPVAIAAKASQTTPIDEEHVEQEKDTENSAAVRTLLFTIEDQSSANASTQTDLLPLRHRLVGPIKPPRPVQECLDILNSTEEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSVRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSIAVNSANNPLNVTVSSCSTIS.
For Research Use Only | Not For Clinical Use.
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