AibGenesis™ Mouse Anti-Pabp Antibody (CBMOAB-27121FYA)


Cat: CBMOAB-27121FYA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-27121FYA Monoclonal Fruit fly (Drosophila melanogaster), A. aegpti (Aedes aegpti), Drosophila melanogaster, Purple sea urchin (Strongylocentrotus purpuratus), Silkworm (Bombyx mori) WB, ELISA MO27121FYA 100 µg
Inquiry
MO-AB-05136Y Monoclonal A. aegpti (Aedes aegpti) WB, ELISA MO05136Y 100 µg
Inquiry
MO-AB-30832H Monoclonal Purple sea urchin (Strongylocentrotus purpuratus) WB, ELISA MO30832C 100 µg
Inquiry
MO-AB-70210W Monoclonal Silkworm (Bombyx mori) WB, ELISA MO70210W 100 µg
Inquiry
MOFY-1222-FY168 Polyclonal Drosophila melanogaster WB, IHC, ICC, IF, ELISA 100 µg
Inquiry

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFruit fly (Drosophila melanogaster), A. aegpti (Aedes aegpti), Drosophila melanogaster, Purple sea urchin (Strongylocentrotus purpuratus), Silkworm (Bombyx mori)
CloneMO27121FYA
SpecificityThis antibody binds to fruit fly Pabp.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationOther locations; Nucleus; Cytosol

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionBinds the poly(A) tail of mRNA (PubMed:2125288). Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex (PubMed:28388438). Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively (PubMed:28388438). The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors, whereas the repressor complex (Atx2-Not1 repressor complex) promotes Not1-dependent post-transcriptional gene silencing and supports high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). In 0-1 hour embryos, forms a ribonucleoprotein complex (RNP) with me31B, eIF4E1, tral and cup which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition (PubMed:28875934). (From uniprot, under CC BY 4.0)
Product OverviewMouse Anti-D. melanogaster Pabp Antibody is a mouse antibody against Pabp. It can be used for Pabp detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesPolyadenylate-binding protein; PABP; Poly(A)-binding protein; pAbp
UniProt IDP21187
Protein RefseqThe length of the protein is 634 amino acids long.
The sequence is show below: MASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNFDLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSKGYGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFDDEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYVARAQKKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEGRSKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQYMRHMTGMRMQQLGQIYQPNAASGFFVPTLPSNQRFFGSQVATQMRNTPRWVPQVRPPAAIQGVQAGAAAAGGFQGTAGAVPTQFRSAAAGARGAQPQVQGTHAAAAAANNMRNTGARAITGQQTAAPNMQIPGAQIAGGAQQRTSNYKYTSNMRNPPVPQLHQTQPIPQQLQGKNSEKLIASLLANAKPQEQKQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVLQVHRVTEPAN.
For Research Use Only | Not For Clinical Use.
Online Inquiry