Mouse Anti-PTPRC Antibody (MOFY-0522-FY78)


Cat: MOFY-0522-FY78
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Specifications

Host speciesMouse
Species ReactivityHuman, Horse
ImmunogenT cells purified from human lymph nodes
FormatLiquid
BufferPBS
Regulatory StatusFor Research Use Only. Not For Clinical Use.
ShippingGel Pack
StorageStore at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.

Application Information

ApplicationFC
Application NotesThe optimal dilution should be determined by the end user.

Target

IntroductionProtein tyrosine phosphatase, receptor type, C, also known as PTPRC, is an enzyme encoded by the PTPRC gene in humans. PTPRC is also called CD45 antigen (CD stands for differentiation cluster) and was originally called Leukocyte Common Antigen (LCA).

The protein product of this gene, most famously CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTP is a signaling molecule that regulates various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

CD45 is a type I transmembrane protein and exists in various isoforms in all differentiated hematopoietic cells (except red blood cells and plasma cells). CD45 has been shown to be an important regulator of T cell and B cell antigen receptor signal transduction. It plays a role by directly interacting with the components of the antigen receptor complex through its extracellular domain (a form of co-stimulation), or through its cytoplasmic domain to activate various Src family kinases required for antigen receptor signal transduction. CD45 can also inhibit JAK kinase, so it can be used as a negative regulator of cytokine receptor signal transduction.
Product OverviewMouse Anti-PTPRC Antibody (MOF032922W246) is a Mouse antibody against PTPRC. It can be used for PTPRC detection in Flow Cytometry.
Alternative NamesPTPRC; B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; protein tyrosine phosphatase; receptor type C; protein tyrosine phosphatase receptor type C
Gene ID100061950(Horse)
For Research Use Only | Not For Clinical Use.

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