Mouse Anti-Rabbit TOP3A Antibody (MO-AB-10283Y)
Cat: MO-AB-10283Y
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Rabbit (Oryctolagus cuniculus) |
Clone | MO10283Y |
Specificity | This antibody binds to Rabbit TOP3A. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Nucleus; Other locations; Mitochondrion |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. |
Product Overview | This product is a mouse antibody against TOP3A. It can be used for TOP3A detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
Alternative Names | DNA topoisomerase; EC 5.99.1.2; TOP3A |
UniProt ID | G1SQY7 |
Protein Refseq | The length of the protein is 993 amino acids long. The sequence is show below: MIFPVARCALRWWLRRPGERASSRAAMEVALRGARKVLCVAEKNDAAKGIADLLSGGRMRRREGLSKFNKIYEFDYHLCGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLALFDAEIEKYCPDNFVDIKKTLERETRQCQALLIWTDCDREGENIGFEIIHVCKAVKPGLQVLRARFSEITPRAVRAACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKIFPQVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHRIKVTHAHRDGVVEFHWKRHRLFNHTACLVLYQLCMEDPTATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPKDLNLTALVEQQTQDPRWGAFAQSILERGGPSPRNGNKSDQAHPPIHPTKYASSLQGDDQRLYEFIVRHFLACCSQDAQGQETTVEINIAQERFVAHGLVILARNYLDVYPYDHWSDKLLPIYEQGSRFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKKDKSVVLRQQVQKYKQVFIEAVAKAKKLDEALSQYFGEGTEVAQQEELYPSLPEPIRKCPQCHKDMVLKAKKHGGFYLSCTGFPECRSAVWFPDSVLEASRDESVCPVCQPHPVYRVKFKFKRGSLPPTMPLEFVGCVGGCDETLREILDLRFSRGPPRASQPASQPSGHLQASQYLNRMDSRRHGHAQPPDGRQSGPSKAPARALPGPHGRRHGRRHVCNCGQEAVLLTRKEGPNQGRQFYKCGAGGCSFFLWADSSPPAGGPPASAPRPPPGSGGHGEGGAGAASCLCSQPAVTRTVQKDGPNKGRQFHTCSKPREQQCGFFQWADENTAPGTFGAAPWPGGRGRAQGPEARSKRPRAGSSDAPGATAKKPRKCSLCHQPGHTRPFCPQNR. |
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For Research Use Only | Not For Clinical Use.
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