Anti-SDHB Antibody (Cat MO-MMB-0633), Rabbit IgG


Cat: MO-MMB-0633
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
ImmunogenKLH coupling synthetic peptide between 137-162 amino acids in the central region of DANRE sdhb.
EpitopeCenter
FormatLiquid or Lyophilized
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use

Application Information

ApplicationWB
Application NotesWB: 1:1000
The optimal dilution should be determined by the end user.

Target

IntroductionComplex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Alternative NamesSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; EC 1.3.5.1; Iron-sulfur subunit of complex II; Ip; sdh
Gene ID562149
UniProt IDA5PL98
For Research Use Only | Not For Clinical Use.
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