AibGenesis™ Mouse Anti-Smn Antibody (CBMOAB-31338FYA)
Cat: CBMOAB-31338FYA
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
- Product List
- Specifications
- Application Information
- Target
| Sub Cat | Clonality | Species Reactivity | Application | Clone | Conjugate | Size | |
| CBMOAB-31338FYA | Monoclonal | Fruit fly (Drosophila melanogaster), Cat (Felis catus), Cattle (Bos taurus), Chicken (Gallus gallus), Dog (Canis lupus familiaris), Drosophila melanogaster | WB, ELISA | MO31338FYA | 100 µg | ||
| MO-AB-04068Y | Monoclonal | Chicken (Gallus gallus) | WB, ELISA | MO04068Y | 100 µg | ||
| MO-AB-07672W | Monoclonal | Cat (Felis catus) | WB, ELISA | MO07672W | 100 µg | ||
| MO-AB-20607R | Monoclonal | Cattle (Bos taurus) | WB, ELISA | MO20607R | 100 µg | ||
| MO-AB-33456W | Monoclonal | Dog (Canis lupus familiaris) | WB, ELISA | MO33456W | 100 µg | ||
| MOFY-1222-FY210 | Polyclonal | Drosophila melanogaster | WB, IHC, ICC, IF, ELISA | 100 µg |
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Fruit fly (Drosophila melanogaster), Cat (Felis catus), Cattle (Bos taurus), Chicken (Gallus gallus), Dog (Canis lupus familiaris), Drosophila melanogaster |
| Clone | MO31338FYA |
| Specificity | This antibody binds to fruit fly Smn. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Plasma Membrane; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non-target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons (PubMed:23063130 and PubMed:23063131). However, Smn is required in motor neurons, but not in cholinergic neurons, for normal motor behavior but plays no role in synaptic transmission according to PubMed:23103409. In both muscle and neurons, required for the formation of a normal neuromuscular junction (NMJ) structure. Plays a neuron-specific role in long-term homeostatic compensation at the larval NMJ. In the thorax of adult flies, required for Act88F, an indirect flight muscle (IFM)-specific actin, expression and for proper IFM myofibril formation. In nurse cells, oocytes and follicle cells, required to maintain normal organization of nuclear compartments including chromosomes, nucleoli, Cajal bodies, histone locus bodies and heterochromatin. Required for the functional integrity of the cytoplasmic U snRNP body (U body) and P body. Required in dividing postembryonic neuroblasts (pNBs) for the correct basal localization of mira. The tight regulation of its expression is critical for stem cell division, proliferation and differentiation in male germline and developing central nervous system (CNS). Required for tracheal terminal cell lumen formation. (From uniprot, under CC BY 4.0) |
| Product Overview | Mouse Anti-D. melanogaster Smn Antibody is a mouse antibody against Smn. It can be used for Smn detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Survival motor neuron protein; Smn |
| UniProt ID | Q9VV74 |
| Protein Refseq | The length of the protein is 226 amino acids long. The sequence is show below: MSDETNAAVWDDSLLVKTYDESVGLAREALARRLADSTNKREEENAAAAEEEAGEISATGGATSPEPVSFKVGDYARATYVDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLLVDLLPSWGKRVRREQFLIAKKDEDEQLSRPKASAGSHSKTPKSSRRSRISGGLVMPPMPPVPPMIVGQGDGAEQDFVAMLTAWYMSGYYTGLYQGKKEASTTSGKKKTPKK. |
For Research Use Only | Not For Clinical Use.
Online Inquiry