AibGenesis™ Mouse Anti-SRB7 Antibody (CBMOAB-04196CR)


Cat: CBMOAB-04196CR

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Lot Number

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Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-04196CR Monoclonal Yeast, C. elegans (Caenorhabditis elegans) WB, ELISA MO04196CR 100 µg
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CBMOAB-10293HCB Monoclonal C. elegans (Caenorhabditis elegans) WB, ELISA MO10293HB 100 µg
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityYeast, C. elegans (Caenorhabditis elegans)
CloneMO04196CR
SpecificityThis antibody binds to Yeast SRB7.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. (From uniprot, under CC BY 4.0)
Product OverviewMouse Anti-Yeast SRB7 Antibody is a mouse antibody against SRB7. It can be used for SRB7 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesMediator of RNA polymerase II transcription subunit 21; Mediator complex subunit 21; RNAPII complex component SRB7; Suppressor of RNA polymerase B 7; SRB7; MED21; YDR308C
UniProt IDP47822
Protein RefseqThe length of the protein is 140 amino acids long. The sequence is show below: MTDRLTQLQICLDQMTEQFCATLNYIDKNHGFERLTVNEPQMSDKHATVVPPEEFSNTIDELSTDIILKTRQINKLIDSLPGVDVSAEEQLRKIDMLQKKLVEVEDEKIEAIKKKEKLLRHVDSLIEDFVDGIANSKKST.
For Research Use Only | Not For Clinical Use.
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