Rabbit Anti-TG Antibody (MOFY-0722-FY317)


Cat: MOFY-0722-FY317
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Specifications

Host speciesRabbit
Species ReactivityBovine
ImmunogenNative Thyroglobulin (TG)
FormatLiquid or Lyophilized
Buffer0.01M PBS, pH7.4, 50% glycerol
Regulatory StatusFor Research Use Only. Not For Clinical Use.
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationProtein A

Application Information

ApplicationWB, IHC, ICC, IP
Application NotesWB: 0.5-2 µg/mL
IHC: 5-20 µg/mL
ICC: 5-20 µg/mL
The optimal dilution should be determined by the end user.

Target

IntroductionThyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Alternative NamesThyroglobulin; AITD3; TGN; Tg;
For Research Use Only | Not For Clinical Use.
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