Rabbit Anti-top2a Antibody (Cat MO-DKB-03661W)
Cat: MO-DKB-03661W
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Human (Homo sapiens), Zebrafish (Danio rerio) |
| Specificity | This antibody is binds to Human TOPO II Alpha and has cross reactivity with Zebrafish TOPO II Alpha. |
| Immunogen | KLH conjugated synthetic phosphopeptide around the phosphorylation site of Ser1106, derived from human TOPO II Alpha |
| Format | Liquid or Lyophilized |
| Buffer | 1% BSA, 50% Glycerol |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Protein A purified |
| Cellular Localization | Nucleus |
Application Information
| Application | WB, ELISA, IHC-P, IHC-Fr, IF |
| Application Notes | Western Blot: 1:300-1000 Enzyme-Linked Immunosorbent Assay: 1:500-1000 Immunohistochemistry-Paraffin 1:200-400 Immunohistochemistry-Frozen: 1:100-500 Immunofluorescence:(Immunohistochemistry-Paraffin) 1:50-200 Immunofluorescence:(Immunohistochemistry-F) 1:50-200 Immunofluorescence/Immunocytochemistry: 1:50-200 The optimal dilution should be determined by the end user. |
Target
| Introduction | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
| Product Overview | This product is a Rabbit antibody against the TOPO II Alpha. It can be used for TOPO II Alpha detection in Western Blot, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunofluorescence. |
| Alternative Names | DNA topoisomerasealpha; DNA topoisomerase 2-alpha; DNA topoisomerase II; alpha isozyme; TOP2; TP2A; TOP2A; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA Topoisomerase2; TOP 2A; TopII alpha; Topo II alpha; Topoisomerase DNA II alpha 170kDa; Topoisomerase II alpha 170 kDa; TOP2A_HUMAN. |
| UniProt ID | A8E7K3 |
See other products for " TOP2A "
| MO-AB-08373W | Mouse Anti-Cat TOP2A Antibody (MO-AB-08373W) |
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| MO-AB-26890W | Mouse Anti-Chimpanzee TOP2A Antibody (MO-AB-26890W) |
| MO-AB-08627H | Mouse Anti-Frog top2a Antibody (MO-AB-08627H) |
| MO-AB-35867W | Mouse Anti-Ferret TOP2A Antibody (MO-AB-35867W) |
| MO-AB-66693W | Mouse Anti-Marmoset TOP2A Antibody (MO-AB-66693W) |
| MO-AB-33911H | Mouse Anti-Nile tilapia top2a Antibody (MO-AB-33911H) |
| MO-AB-04540Y | Mouse Anti-Chicken TOP2A Antibody (MO-AB-04540Y) |
| CBMOAB-60843FYA | Mouse Anti-Rhesus TOP2A Antibody (CBMOAB-60843FYA) |
| MO-AB-22042R | Mouse Anti-Cattle TOP2A Antibody (MO-AB-22042R) |
For Research Use Only | Not For Clinical Use.
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