Mouse Anti-Zebrafish il7r Antibody (CBMOAB-80704FYA)


Cat: CBMOAB-80704FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityZebrafish (Danio rerio)
CloneMO80704FYA
SpecificityThis antibody binds to Zebrafish il7r.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
Product OverviewMouse Anti-Zebrafish il7r Antibody is a mouse antibody against il7r. It can be used for il7r detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Namesil7r; Interleukin 7 Receptor
UniProt IDE9QDP8
Protein RefseqThe length of the protein is 372 amino acids long.
The sequence is show below: MAGLLWIIFVVFCPLGLSESGDGDLPDKEVTCTSTLTLMQNILYCFPNDEPIEEVIFATLCKMKEKSKCTNATLGPKYFSFENLENIVKYELQVHLRDGIIEKEIDLTKMVKIPAPELKSATFLKETDEIFIWFEHRHDYVRQCQFQVEIRGEHEPISLLVDYKNISMSRDRLGGDGVYSTRVRAKPINYFAGDWSEWSSDANFTIKTKNHAPIQTPQVVTGILTIILVLIISLIALRWRTQIKKYITPNIPHPKATLAQMQRAKEGLPFTFSPEIFSDAFIHRVDYVDEKPSAPELQDELRYSSSSASVSEMDMNADERLPREQSHLKIRLLDESDLEKEMENSVSQGLKSPQLECKEEAYVTMSSLFKTQ.

Reference

Reference1. Cai, S., Chen, Y., Shang, Y., Cui, J., Li, Z., & Li, Y. (2018). Knockout of zebrafish interleukin 7 receptor (IL7R) by the CRISPR/Cas9 system delays retinal neurodevelopment. Cell death & disease, 9(3), 273.
2. Morrison, J. K., DeRossi, C., Alter, I. L., Nayar, S., Giri, M., Zhang, C., ... & Chu, J. (2022). Single-cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver. Hepatology Communications, 6(7), 1711-1724.
3. Borga, C., Park, G., Foster, C., Burroughs-Garcia, J., Marchesin, M., Shah, R., ... & Frazer, J. K. (2019). Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis. Leukemia, 33(2), 333-347.
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For Research Use Only | Not For Clinical Use.
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