Mouse Anti-Zebrafish mcm6 Antibody (CBMOAB-86314FYA)


Cat: CBMOAB-86314FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityZebrafish (Danio rerio)
CloneMO86314FYA
SpecificityThis antibody binds to Zebrafish mcm6.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Product OverviewMouse Anti-Zebrafish mcm6 Antibody is a mouse antibody against mcm6. It can be used for mcm6 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Namesmcm6; Minichromosome Maintenance Complex Component 6
UniProt IDF1R5P3
Protein RefseqThe length of the protein is 830 amino acids long.
The sequence is show below: MDLTETGVNQNAGQVIKDELAEKCQKLFQAFLEEFQNSDGEVKYLRDAEELIRPERNTLAVSFTDLEGFNQELATAIQEEFYRLYPYLCRAVRNFARDHGEVPTSKEFYVAFQDLPTRHKIRELTTVKVGSLVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKDVEQQFKYTQPSICRNPVCNNRRRFLLDTNKSKFIDFQKVRIQETQAELPRGSIPRSMEVILRAEAVESAQAGDKCDFIGSLIVVPDISQLATPGVRAETSSRTAGVQGYENEGLRGLKALGVRELSYKLAFLACHVAPTNPRFGGKEIRDEEQTAESIKKQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDINVCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLHSRIENSVDRVYSLDEIRRYLLFARQFKPKISKESEEFIVEQYKRLRQRDGSGVTKSAWRITVRQLESLIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEEAMEEEEDNQMNGHDVPNGVNGAVNGEVNGHEHTNGINGHGVNGETAKPSLRLSFAEYKRISNLLVLHLRRAEEDEDEAALKKSEVVNWYLKEIESEIDSEMELISKKTMIEKVIYRLVHYDYILIELKQSGLKGSAESSETESQEEDVTLVVNPNYTFED.
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For Research Use Only | Not For Clinical Use.
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