AibGenesis™ Mouse Anti-cpxP Antibody (CBMOAB-0416YC)


Cat: CBMOAB-0416YC

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Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-0416YC Monoclonal E. coli (Escherichia coli ), E. coli WB, ELISA MO0416YC 100 µg
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MOXC-002W Monoclonal E. coli WB, ELISA XM02
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MOXC-003W Monoclonal E. coli WB, ELISA XM03
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MOXC-004W Monoclonal E. coli WB, ELISA XM04
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityE. coli (Escherichia coli ), E. coli
CloneMO0416YC
SpecificityThis antibody binds to Escherichia coli K-12 cpxP.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionActs as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers (PubMed:25207645, PubMed:16303867). Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity (PubMed:16166523, PubMed:21317318). Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway (PubMed:16166523, PubMed:16303867). Aids in combating extracytoplasmic protein-mediated toxicity (PubMed:9473036, PubMed:16303867, PubMed:21239493). Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE) (PubMed:21239493). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50% but has no effect on phosphatase activity of CpxA (PubMed:17259177, PubMed:21239493). Has mild protein chaperone activity (PubMed:21317898, PubMed:21239493). (From uniprot, under CC BY 4.0)
Product OverviewMouse Anti-E. coli cpxP Antibody is a mouse antibody against cpxP. It can be used for cpxP detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative NamesPeriplasmic protein CpxP; cpxP; yiiO; b4484 JW5558
UniProt IDP0AE85
Protein RefseqThe length of the protein is 166 amino acids long. The sequence is show below: MRIVTAAVMASTLAVSSLSHAAEVGSGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSELETMHRLVTAENFDENAVRAQAEKMANEQIARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSSSNSRSQ.
For Research Use Only | Not For Clinical Use.
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