Mouse Anti-cpxR Antibody (CBMOAB-0417YC)


Cat: CBMOAB-0417YC
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Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-0417YC Monoclonal E. coli (Escherichia coli ), E. coli WB, ELISA MO0417YC 100 µg
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MOXC-005W Monoclonal E. coli WB, ELISA XM05
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MOXC-006W Monoclonal E. coli WB, ELISA XM06
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MOXC-007W Monoclonal E. coli WB, ELISA XM07
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityE. coli (Escherichia coli ), E. coli
CloneMO0417YC
SpecificityThis antibody binds to Escherichia coli K-12 cpxR.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionResponse regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed:11830644). Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced) (PubMed:11830644). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).
Product OverviewMouse Anti-E. coli cpxR Antibody is a mouse antibody against cpxR. It can be used for cpxR detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative NamesTranscriptional regulatory protein CpxR; cpxR; yiiA; b3912 JW3883
UniProt IDP0AE88
Protein RefseqThe length of the protein is 232 amino acids long. The sequence is show below: MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS.
For Research Use Only | Not For Clinical Use.
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