Rabbit Anti-IL1B (AA 110-130) Antibody (Cat MO-MMB-0060)


Cat: MO-MMB-0060
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman, Mouse, Rat, Zebrafish
SpecificityThis antibody is binds to Human IL1B and has cross reactivity with Mouse, Rat, Zebrafish IL1B.
ImmunogenA synthetic peptide derived from human IL1B (accession number P01584), corresponding to amino acid residues N110-Q130.
EpitopeAA 110-130
FormatLiquid or Lyophilized
BufferPBS , pH 7.4, 150mM NaCl, 50% glycerol
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationPeptide affinity chromatography

Application Information

ApplicationWB, IHC, IF
Application NotesWB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Product OverviewThis product is a Rabbit antibody against the epitope AA 110-130 of IL1B. It can be used for IL1B detection in Western Blot, Immunohistochemistry, Immunofluorescence.
Alternative NamesInterleukin 1 Beta
Gene ID3553
UniProt IDP01584
For Research Use Only | Not For Clinical Use.
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