ATP-binding cassette sub-family C member 8
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.
Mouse Anti-ABCC8 Antibody (MO-AB-50203W) (CAT#: MO-AB-50203W)
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- Host species: Mouse
- Species Reactivity: Marmoset, A. thaliana (Arabidopsis thaliana), Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Submitted name: ATP-binding cassette sub-family C member 8
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: ATP-binding cassette sub-family C member 8, ABCC8
Mouse Anti-ABCC8 (AA 1548-1582, clone NW0157) Antibody (MO-NAB-00040W) (CAT#: MO-NAB-00040W)
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- Host species: Mouse
- Species Reactivity: Hamster (Cricetulus griseus), Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), A. thaliana (Arabidopsis thaliana), Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
- Application: WB, IHC, IF
- Protein: ATP-binding cassette sub-family C member 8
- Size: 100µg
- Conjugate: Conjugated available
- Alternative Names: ATP Binding Cassette Subfamily C Member 8, ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8, Sulfonylurea Receptor (Hyperinsulinemia), Sulfonylurea Receptor 1, HRINS, SUR1, SUR, ATP-Binding Cassette Transporter Sub-Family C Member 8, ATP-Binding Cassette Sub-Family C Member 8
