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Mouse Anti-ABCC8 (AA 1548-1582, clone NW0157) Antibody (MO-NAB-00040W)


Cat: MO-NAB-00040W
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityHamster (Cricetulus griseus), Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
CloneNW0157
SpecificityDetects ~160kDa. Does not cross-react with SUR2B.
ImmunogenFusion protein of rat SUR1 (C-terminal cytoplasm).
EpitopeAA 1548-1582
FormatLiquid
BufferPBS, pH7.4, 50% glycerol
Storage−20°C
PurificationProtein G Purified
Cellular LocalizationMembrane

Application Information

ApplicationWB, IHC, IF
Application NotesWB: 1/1000
IHC: 1/1000
IF: 1/100
Assay-dependent

Target

IntroductionThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Product OverviewMouse Anti-ABCC8 (AA 1548-1582, clone NW0157) Antibody (MO-NAB-00040W) is a Mouse antibody against the epitope (AA 1548-1582) of theSUR1. It can be used for SUR1 detection in Western Blot, Immunohistochemistry, Immunofluorescence.
Alternative NamesATP Binding Cassette Subfamily C Member 8; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8; Sulfonylurea Receptor (Hyperinsulinemia); Sulfonylurea Receptor 1; HRINS; SUR1; SUR; ATP-Binding Cassette Transporter Sub-Family C Member 8; ATP-Binding Cassette Sub-Family C Member 8
Gene ID6833
UniProt IDQ09428
For Research Use Only | Not For Clinical Use.

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