Mouse Anti-ABCC8 (AA 1548-1582, clone NW0157) Antibody (MO-NAB-00040W)
Cat: MO-NAB-00040W
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Hamster (Cricetulus griseus), Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus) |
| Clone | NW0157 |
| Specificity | Detects ~160kDa. Does not cross-react with SUR2B. |
| Immunogen | Fusion protein of rat SUR1 (C-terminal cytoplasm). |
| Epitope | AA 1548-1582 |
| Format | Liquid or Lyophilized |
| Buffer | PBS, pH7.4, 50% glycerol |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Protein G Purified |
| Cellular Localization | Membrane |
Application Information
| Application | WB, IHC, IF |
| Application Notes | WB: 1/1000 IHC: 1/1000 IF: 1/100 Assay-dependent |
Target
| Introduction | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] |
| Product Overview | Mouse Anti-ABCC8 (AA 1548-1582, clone NW0157) Antibody (MO-NAB-00040W) is a Mouse antibody against the epitope (AA 1548-1582) of theSUR1. It can be used for SUR1 detection in Western Blot, Immunohistochemistry, Immunofluorescence. |
| Alternative Names | ATP Binding Cassette Subfamily C Member 8; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8; Sulfonylurea Receptor (Hyperinsulinemia); Sulfonylurea Receptor 1; HRINS; SUR1; SUR; ATP-Binding Cassette Transporter Sub-Family C Member 8; ATP-Binding Cassette Sub-Family C Member 8 |
| Gene ID | 6833 |
| UniProt ID | Q09428 |
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For Research Use Only | Not For Clinical Use.
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