Class II transactivator
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Mouse Anti-Rhesus CIITA Antibody (CBMOAB-39278FYA) (CAT#: CBMOAB-39278FYA)
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- Host species: Mouse
- Species Reactivity: Rhesus (Macaca mulatta)
- Application: WB, ELISA
- Protein: Submitted name: MHC class II transactivator
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: MHC class II transactivator, CIITA
Mouse Anti-Chicken CIITA Antibody (MO-AB-01211Y) (CAT#: MO-AB-01211Y)
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- Host species: Mouse
- Species Reactivity: Chicken (Gallus gallus)
- Application: WB, ELISA
- Protein: Submitted name: Class II transactivator
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Class II transactivator, CIITA
Mouse Anti-Pig CIITA Antibody (MO-AB-24614R) (CAT#: MO-AB-24614R)
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- Host species: Mouse
- Species Reactivity: Pig (Sus scrofa)
- Application: WB, ELISA
- Protein: Submitted name: Class II major histocompatibility complex transactivator
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: MHC class II transactivator, CIITA
Mouse Anti-Zebrafish ciita Antibody (CBMOAB-70554FYA) (CAT#: CBMOAB-70554FYA)
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- Host species: Mouse
- Species Reactivity: Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Submitted name: Class II, major histocompatibility complex, transactivator
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: ciita, Class II Major Histocompatibility Complex Transactivator
