Mouse Anti-Chicken CIITA Antibody (MO-AB-01211Y)


Cat: MO-AB-01211Y
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityChicken (Gallus gallus)
CloneMO01211Y
SpecificityThis antibody binds to Chicken CIITA.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Product OverviewThis product is a mouse antibody against CIITA. It can be used for CIITA detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative NamesClass II transactivator; CIITA
UniProt IDW0K996
Protein RefseqThe length of the protein is 562 amino acids long. The sequence is show below: ICQDWSNGEFPQFEFVFWFDCKQISLPEKWYSLKDLLLDFFVRPQEGSKEIFKYILQNSTKVLLVFDGLEGLHGHENSPQCSASQPNKDLCRVKELLSGLIQKKILNGCTLLLTARTKEKVCQYVSKVDKTIEIVGFSPWQRELYISKYFEGLPSCDNALNLIKEHEYLFSHCYSPVMCRFVCFLCETILEMGDQGLPSTLTTLFLKFVQQKIMPTQTDVTDVTLAQNQENLATLACIAWYLGEKHLSAMKSDLLPSKEVKEFALKNGFFLPFAFPKHSDTGEEEYGTMFSDFVIQNFLGALHLILTEGIKNKSLIKYLSFPSKKKKPYNWLHFVPRFLAGLLFLQDDTYFCSLSNKGVKKSTKKQKMLLKYIKRLQINNLCPERLLELLHCIYETQNSYLLQHVALRLKPDLSFLGIVLTPPDVHVLSSTLKRSRKEFSLDLQNSSIDTHGLKDLVGLKNVVSFRASLSDTIRLWKYLEQTKDYELLRVSTEKFVLDPFKAKIMRDIIDLSDLVEMQEIIINRVQDDSGCSSYQIPAIKNLRKLEFALGPACGLQGFLKLV.
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MO-AB-24614RMouse Anti-Pig CIITA Antibody (MO-AB-24614R)
For Research Use Only | Not For Clinical Use.
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