Deoxyuridine 5'-triphosphate nucleotidohydrolase
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Mouse Anti-DUT Antibody (MO-AB-54601W) (CAT#: MO-AB-54601W)
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- Host species: Mouse
- Species Reactivity: Marmoset, A. thaliana (Arabidopsis thaliana), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Frog (Xenopus laevis), Rat (Rattus norvegicus), Rhesus (Macaca mulatta), Rice (Oryza), Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1, DUT
Mouse Anti-dut Antibody (CBMOAB-0629YC) (CAT#: CBMOAB-0629YC)
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- Host species: Mouse
- Species Reactivity: E. coli (Escherichia coli ), A. thaliana (Arabidopsis thaliana), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Frog (Xenopus laevis), Rat (Rattus norvegicus), Rhesus (Macaca mulatta), Rice (Oryza), Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, None, PE, PerCP
- Alternative Names: Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, EC 3.6.1.23, dUTP pyrophosphatase, dut, dnaS sof, b3640 JW3615
