TLR4 Gene(Protein Coding) Toll Like Receptor 4
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Mouse Anti-TLR4 Antibody (MOFY-0722-FY58) (CAT#: MOFY-0722-FY58)
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- Host species: Mouse
- Species Reactivity: Goat, Cat (Felis catus), Cattle (Bos taurus), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Donkey (Equus asinus), Elephant (Loxodonta africana), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Goat (Capra hircus), Guinea pig (Cavia porcellus), Hamsters (Cricetinae), Horse (Equus caballus), Human (Homo sapiens), Mouse (Mus musculus), Bovine (Bos taurus), Mammal, Primat, Rhesus (Macaca mulatta), Rat (Rattus norvegicus), Mallard (Anas platyrhynchos), Marmoset, Pig (Sus scrofa), Rabbit (Oryctolagus cuniculus), Sheep (Ovis aries), Zebrafish (Danio rerio)
- Application: WB, IHC, ICC, IP
- Protein: TLR4 Gene(Protein Coding) Toll Like Receptor 4
- Size: 100µL
- Conjugate: None
- Alternative Names: Toll Like Receptor 4, Toll-Like Receptor 4, HToll, Homolog Of Drosophila Toll, CD284 Antigen, ARMD10, CD284, TLR-4, TOLL
