Rabbit Anti-AKT1 Antibody (MO-DKB-00540W)


Cat: MO-DKB-00540W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityFruit fly (Drosophila melanogaster)
ImmunogenThe synthesized phosphopeptide corresponds to the amino acid residues conjugated to KLH around Thr342. Registration number # Q8INB9
FormatLiquid or Lyophilized
Buffer10 mM HEPES, pH 7.5, 150 mM NaCl, 100 ug per ml BSA and 50% glycerol
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurityAffinity purified

Application Information

ApplicationWB
Application NotesWestern Blot 1:100-1:2000

Target

IntroductionThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Product OverviewThis product is a Rabbit antibody against the AKT1. It can be used for AKT1 detection in Western Blot.
Alternative NamesAKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase;
Gene ID207
UniProt IDP31749
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For Research Use Only | Not For Clinical Use.
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