Mouse Anti-ATM Antibody (MOFAB-051W)
Cat: MOFAB-051W
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Specificity | This antibody recognizes full-length ATM, a 370 kD nucleophosmin involved in the autorecessive genetic disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins involved in cell cycle regulation and DNA repair responses. The C-terminal region shares extensive homology with the catalytic domain of phosphatidylinositol 3-kinase (PI3 kinase). Its usefulness for monitoring altered ATM expression in cancer is under active investigation. |
| Immunogen | The GST fusion protein expressed in E. coli corresponds to amino acids 2577-3056 of full-length ATM. |
| Format | Liquid or Lyophilized |
| Buffer | PBS, pH 7.4 |
| Regulatory Status | For Research Use Only |
| Shipping | Gel Pack |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Protein G |
Application Information
| Application | IB, IP |
| Application Notes | IB: 1-10 ug/ml IP: 1-10 ug/ml The optimal dilution should be determined by the end user. |
Target
| Introduction | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. |
| Product Overview | The ATM antibody is used as Cancer Research. |
| Alternative Names | ATM Serine/Threonine Kinase; Ataxia Telangiectasia Mutated; A-T Mutated; EC 2.7.11.1; Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D); TEL1, Telomere Maintenance 1, Homolog (S. Cerevisiae); TEL1, Telomere Maintenance 1, Homolog; Serine-Protein Kinase ATM; AT Mutated; ATM |
| Gene ID | 472 |
| UniProt ID | Q13315 |
See other products for " ATM "
| CBMOAB-24677FYC | Mouse Anti-Arabidopsis ATM Antibody (CBMOAB-24677FYC) |
| CBMOAB-36516FYA | Mouse Anti-Rhesus ATM Antibody (CBMOAB-36516FYA) |
| MO-AB-23928R | Mouse Anti-Pig ATM Antibody (MO-AB-23928R) |
| MO-AB-24204W | Mouse Anti-Chimpanzee ATM Antibody (MO-AB-24204W) |
| CBMOAB-66956FYA | Mouse Anti-Zebrafish atm Antibody (CBMOAB-66956FYA) |
| MO-AB-30576H | Mouse Anti-Purple sea urchin ATM Antibody (MO-AB-30576H) |
| MO-AB-01687H | Mouse Anti-Frog atm Antibody (MO-AB-01687H) |
| MO-AB-00211Y | Mouse Anti-Chicken ATM Antibody (MO-AB-00211Y) |
| MO-AB-29073W | Mouse Anti-Dog ATM Antibody (MO-AB-29073W) |
For Research Use Only | Not For Clinical Use.
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