Mouse Anti-C. elegans RAD50 Antibody (CBMOAB-08977HCB)


Cat: CBMOAB-08977HCB
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityC. elegans (Caenorhabditis elegans)
CloneMO08977HB
SpecificityThis antibody binds to C. elegans RAD50.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Product OverviewMouse Anti-C. elegans RAD50 Antibody is a mouse antibody against RAD50. It can be used for RAD50 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesProtein RAD-50, isoform b; rad-50
UniProt IDA5JYU5
Protein RefseqThe length of the protein is 1312 amino acids long. The sequence is show below: MRRKYLLIEAWELLMAKFLRLHIRGIRSVGDEDHDVHKIDFLSPCTLISGPNGTGKTTTIEALNFVTTGQMPTQKKQNFIHSTDVARKTRVDASVTLEFIDVKGRECTAVRRLVVTSGTKAAALAEEHTLAIKYPDGTVNTLSSKVCDFNTALLKHLGVPRAVFKYVIFCHQEDSTWPLSEPKELKKRFDDIFQLTKFVKAQERMKKIVLDFKKEMQTHEMSKQLYETHVRDKLVARQNQEECERKISKRKEETDELKERKANGQKKIEEMRTSIHELEDTLTSFKKTELERQNLKKQLSLIRVEPYFGTEEELKREIEEFRGSEGRSYGEERARIQKKIGKNNQERQELSQKKTEFENRISSLKAEVIHCQSLKYDLERLENQLRSELDLEHDADIDIEIDNAITLKIRGMSDKARMIAKNCAELQSNLRTAQEAATKIEVEMKTLQNEKVKLEKEVEQLKFKIKQGQNATAGMKDLLKKEEALRKSLADLPLLDENALTECKLKREKYLKQLDILKKKCAEAEKNAEKDREKESLKQTLSIARKKMTAYQRIYDNNWQGLIGQAPDFPWTPILSKTFHKLRNDKKIMEEDLRDVQLNVQKLETMQHQYRKQEESLTAQELKLSENIFEACSCEAEEVSEKLENLRKRLKKARKDLAPLSAKSNLYDSYIEESKSSGCCPLCDRDFKTKKEINEFSKKLENMTLSFPTEQEELEKLVSKLEKEEIIIVKAEGQANELQRIVKELKEVREKNRKLSTEMAEEKSNLSKNEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLSYTELRKKVEDKDEEYRKIVQEGEELQKCSEERNKLQSKLNELGTHRVSLGEAAAQAGAFAEQLETKIKEIQECITAISQKRNEDLPDAQFKKDDLTRNVSSKEEEKKKAEMEVQMMKKELDQKIFHRKSLFKKVQEGGLCERQLMDKENNIATLNASLEENQQRQKRFEEDLRSFDSSHQRESILKDQLTRMIIENKIKELKRTLATFDGQINEDRITEQKQAYNKLQNELRLIGNEEVKIYTQMQEYEKQKKIAEAKLSTKECQNAESNYRDAIIELAITKESISDLTKYRNCLDASLIQFHSEKMGRVNGIIDDLWRKVYNSTDITTIRIRSDATSETSSKKVAYEYNVMMVHETGTEVEMRGRCSAGQKMLASLLIRIALAEVFGGSCSMIALDEPTTNLDESKVEGMAIVLADIIAERRGFDENGKLRGRDMQMVVITHDERLVNRITISCRPEYIYCLGKDEHGISFLSKRYPDGTVKRVNTKRRF.
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For Research Use Only | Not For Clinical Use.
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