Mouse Anti-Chicken AGT Antibody (MO-AB-00085Y)
Cat: MO-AB-00085Y
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Chicken (Gallus gallus) |
Clone | MO00085Y |
Specificity | This antibody binds to Chicken AGT. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Extracellular region or secreted |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. |
Product Overview | This product is a mouse antibody against AGT. It can be used for AGT detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Angiotensinogen; AGT |
UniProt ID | F1NDH2 |
Protein Refseq | The length of the protein is 464 amino acids long. The sequence is show below: MKLAAGLLCLLLCFTAVGCDRVYVHPFSLNAINESACEELERLAQEGKKTFVPASIESQTTPAYEEDVKDEVRLDSPSLSVRGRQKLIYLKDFVHVLGMRFYNLQREARQGQNVLLSPTSLYGSLASFYLGASNQTAADLQGLLGFVPPSGDSNCTSRVDGRKLLESLRTIESLVKTQDEELLFSKVFCLFSAPGILLSQQFVHNLLPSADAFYTRAVDFTNPSEATKQINAFVEAKSKGQSKHLLTDLDPTTDLLVAVDVRLAANAKKASWLKEPQEFWVDSNRAISVPMLSVTGMFKYMTDTSETFSATEIPVGKNVLLVLLQPINGNDLDKVEAKLPLQSSAWLENLSPRKIKLTLPEFRIEDSSDLQEFLADMKLPALLGKEADLSKISDTHLTVGKIMNKAFFKLSSDATHQPEDATAQEEDSVPQEVMLNKPFLLAVFEAKSRAMLFLGRVTNPLQEV. |
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For Research Use Only | Not For Clinical Use.
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