Mouse Anti-Chicken TH Antibody (MO-AB-04669Y)


Cat: MO-AB-04669Y
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityChicken (Gallus gallus)
CloneMO04669Y
SpecificityThis antibody binds to Chicken TH.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationOther locations; Plasma membrane; Nucleus; Endoplasmic reticulum

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionTH is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine and norepinephrine and is responsible for the conversion of L-tyrosine to L-dopa. The synthesis of catecholamines is regulated by the interaction of TH with its cofactor tetrahydrobiopterin (BH4) and the substrates L-tyrosine and molecular oxygen. In humans, four TH mRNA splice variants (hTH1-hTH4) have been isolated, whereas subprimate species rely on a single form of TH. The hTH1-hTH4 variants are known to have identical catalytic domains but different N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a link between this enzyme and many neuropathic diseases characterized by irregular levels of catecholamines, such as Parkinson''s disease, schizophrenia, and dystonia, as well as various cardiovascular disease.
Product OverviewThis product is a mouse antibody against TH. It can be used for TH detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative NamesTyrosine hydroxylase; tyrosine; hydroxylase
UniProt IDQ9PU40
Protein RefseqThe length of the protein is 491 amino acids long. The sequence is show below: MPTPNISTSAAKGFRRAVSELDSKQAEAIMSPRFIGRRQSLIEDARKEREAAAAATDAAESTETIVFEEKDGRAMLNLFFMLKGAKTSPLSRALKVFETFEAKIHHLETRLSRKPREGTAELEYFVRCEVHSSDLNTFISSIKRVAEDVRTTKEDKFHWFPRKICELDKCHHLVTKFDPDLDLDHPGYSDQVYRQRRKSIAEIAFHYKHGDPIPRVEYTAEETATWKEVYSTLKSLYPTHACKEYLEAFNLLEKFCGYNENNIPQLEEVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADKTFAQFSQDIGLASLGATDEEIEKLATLYWFTVEFGLCRQNGIVKAYGAGLLSSYGELIHSLSDEPEVRDFDPDAAAVQPYQDQNYQPVYFVSESFSDAKNKLRNYAAHIKRPFSVKYEPYTHSIELLDSPQTICHSLESVRDELHSLINALNVIS.
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For Research Use Only | Not For Clinical Use.
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