Rabbit Anti-EIF6 (Center) Antibody (Cat MO-DKB-03388W)


Cat: MO-DKB-03388W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Pig (Sus scrofa), Cattle (Bos taurus), Chicken (Gallus gallus), Sheep (Ovis aries), Frog (Xenopus), Zebrafish (Danio rerio)
SpecificityThis antibody is binds to Human integrin beta 4 binding protein and has cross reactivity with Mouse, Rat, Pig, Cattle, Chicken, Sheep, Frog, Zebrafish integrin beta 4 binding protein.
ImmunogenA recombinant protein containing sequences in the central region of human EIF6.
EpitopeCenter
FormatLiquid or Lyophilized
BufferPBS, pH7, 20% Glycerol
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationAffinity purified
Cellular LocalizationCytoplasm, Nucleus

Application Information

ApplicationWB, IHC, IHC-P
Application NotesWestern Blot: 1:1000-1:10000
Immunohistochemistry: 1:100-1:1000
Immunohistochemistry-Paraffin: 1:100-1:1000
The optimal dilution should be determined by the end user.

Target

IntroductionHemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
Product OverviewThis product is a Rabbit antibody against the integrin beta 4 binding protein. It can be used for integrin beta 4 binding protein detection in Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Alternative NamesEukaryotic translation initiation factor 6; eIF-6; eif
UniProt IDB0R0S5
For Research Use Only | Not For Clinical Use.
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