Mouse Anti-Elephant APP Antibody (MO-AB-00093L)
Cat: MO-AB-00093L
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Size: | |
Conjugate: | |
Inquiry |
- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Elephant (Loxodonta africana) |
Clone | MO00093L |
Specificity | This antibody binds to Elephant APP. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (By similarity). Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity). |
Product Overview | This product is a mouse antibody against APP. It can be used for APP detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein |
UniProt ID | Q9BFU6 |
Protein Refseq | The length of the protein is 12 amino acids long. The sequence is show below: NPTYKFFEQMQN. |
See other products for " APP "
MO-AB-07235Y | Mouse Anti-Rabbit APP Antibody (MO-AB-07235Y) |
MO-AB-08377W | Mouse Anti-Cat APP Antibody (MO-AB-08377W) |
CBMOAB-36084FYA | Mouse Anti-Rhesus APP Antibody (CBMOAB-36084FYA) |
MO-AB-07514R | Mouse Anti-Cattle APP Antibody (MO-AB-07514R) |
MO-AB-24129H | Mouse Anti-Rat APP Antibody (MO-AB-24129H) |
MO-AB-51116W | Mouse Anti-Marmoset APP Antibody (MO-AB-51116W) |
MO-AB-14223Y | Mouse Anti-Sheep APP Antibody (MO-AB-14223Y) |
MO-AB-41259W | Mouse Anti-Guinea pig APP Antibody (MO-AB-41259W) |
MO-DKB-00490W | Rabbit Anti-APP Antibody (MO-DKB-00490W) |
MO-AB-01096W | Mouse Anti-Rhesus APP Antibody (MO-AB-01096W) |
For Research Use Only | Not For Clinical Use.
Online Inquiry