Rabbit Anti-fas Antibody (MO-DKB-00114W)
Cat: MO-DKB-00114W
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Zebrafish (Danio rerio) |
| Specificity | This antibody is binds to Zebrafish fas. |
| Immunogen | Recombinant zebrafish Fas cell surface death receptor protein |
| Epitope | The epitope is in the AA 185-293 of fas. |
| Format | Liquid or Lyophilized |
| Buffer | PBS pH 7.4, 50% Glycerol |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 95% was determined by SDS-PAEG |
| Purification | Purified with G affinity chromatography |
Application Information
| Application | ELISA, WB |
| Application Notes | Western Blot: 1:500-1:5000 |
Target
| Introduction | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
| Product Overview | This product is a rabbit antibody against the AA 185-293 of the fas. It can be used for fas detection in Enzyme-Linked Immunosorbent Assay, Western Blot. |
| Alternative Names | fas; Fas Cell Surface Death Receptor |
| UniProt ID | F1QG24 |
See other products for " FAS "
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| CBMOAB-42588FYA | Mouse Anti-Rhesus FAS Antibody (CBMOAB-42588FYA) |
| MO-AB-44719W | Mouse Anti-Horse fas Antibody (MO-AB-44719W) |
| MO-AB-12374R | Mouse Anti-Cattle FAS Antibody (MO-AB-12374R) |
| MO-AB-08050Y | Mouse Anti-Rabbit FAS Antibody (MO-AB-08050Y) |
| CBMOAB-16535FYA | Mouse Anti-D. melanogaster Fas Antibody (CBMOAB-16535FYA) |
| MO-AB-19797W | Mouse Anti-Chimpanzee FAS Antibody (MO-AB-19797W) |
| MO-AB-23203H | Mouse Anti-Mallard FAS Antibody (MO-AB-23203H) |
| MO-AB-25767R | Mouse Anti-Pig FAS Antibody (MO-AB-25767R) |
For Research Use Only | Not For Clinical Use.
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