Rabbit Anti-FEN1 Antibody (MO-DKB-00055W)
Cat: MO-DKB-00055W
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- Product Details
Specifications
Host species | Rabbit (Oryctolagus cuniculus) |
Species Reactivity | A. thaliana (Arabidopsis thaliana) |
Specificity | This antibody is binds to Arabidopsis thaliana FEN1. |
Immunogen | Recombinant Arabidopsis Flap Endonuclease 1 Protein |
Epitope | The epitope is in the AA 85-383 of FEN1. |
Format | Liquid or Lyophilized |
Buffer | PBS pH 7.4, 50% Glycerol |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 95% was determined by SDS-PAEG |
Purification | Purified with G affinity chromatography |
Application Information
Application | ELISA |
Target
Introduction | The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. |
Product Overview | This product is a rabbit antibody against the AA 85-383 of the FEN1. It can be used for FEN1 detection in Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Flap Structure-Specific Endonuclease 1; DNase IV; Maturation Factor-1; FEN-1; RAD2; MF1 |
UniProt ID | O65251 |
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For Research Use Only | Not For Clinical Use.
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