Rabbit Anti-GPX1 Antibody (MO-DKB-00593W)


Cat: MO-DKB-00593W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Primat, Rhesus (Macaca mulatta)
ImmunogenA synthetic peptide containing sequences within the C-terminal region of human GPX1.
EpitopeThe epitope is in the C-terminal of GPX1.
FormatLiquid or Lyophilized
BufferPBS, pH7, 20% Glycerol
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurityAffinity purified
Cellular LocalizationCytoplasm

Application Information

ApplicationWB, IB, IF, IHC, IHC-P
Application NotesWestern Blot 1:1000-1:10000
Immunoblotting
Immunocytochemistry/Immunofluorescence 1:100-1:1000
Immunohistochemistry 1:100-1:1000
Immunohistochemistry-Paraffin 1:100-1:1000

Target

IntroductionThe protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]
Product OverviewThis product is a Rabbit antibody against the C-terminal of the GPX1. It can be used for GPX1 detection in Western Blot, Immunoblotting, Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin.
Alternative NamesGlutathione Peroxidase 1; Cellular Glutathione Peroxidase; EC 1.11.1.9; GSHPx-1; EC 1.11.1; GSHPX1; GPx-1; GPXD;
Gene ID2876
UniProt IDP07203
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MO-AB-02214YMouse Anti-Chicken GPX1 Antibody (MO-AB-02214Y)
MO-AB-00625RMouse Anti-Medaka gpx1 Antibody (MO-AB-00625R)
MO-AB-34857WMouse Anti-Ferret GPX1 Antibody (MO-AB-34857W)
MO-AB-04043HMouse Anti-Frog gpx1 Antibody (MO-AB-04043H)
CBMOAB-01572CRMouse Anti-Yeast GPX1 Antibody (CBMOAB-01572CR)
For Research Use Only | Not For Clinical Use.
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