Rabbit Anti-GPX2 Antibody (MO-DKB-01993W)


Cat: MO-DKB-01993W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityA. thaliana (Arabidopsis thaliana)
ImmunogenGPX2 synthetic peptide derived from Arabidopsis AT2G31570.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurityAffinity purified

Application Information

ApplicationWB
Application NotesWestern Blot (1:1000-1:2000) Note: Optimal dilutions/concentrations should be determined by the end user.

Target

IntroductionThe protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Product OverviewThis product is a Rabbit antibody against the GPX2. It can be used for GPX2 detection in Western Blot.
Alternative NamesGlutathione Peroxidase 2; Glutathione Peroxidase 2 (Gastrointestinal); Glutathione Peroxidase-Related Protein 2; Gastrointestinal Glutathione Peroxidase; EC 1.11.1.9; GSHPX-GI; GSHPx-2; GPRP-2; GPX2, ATGPX2, GLUTATHIONE PEROXIDASE 2, GPXL2
UniProt IDO04922
For Research Use Only | Not For Clinical Use.
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