Rabbit Anti-mlh1 Antibody (MOFY-1222-FY74)


Cat: MOFY-1222-FY74
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Specifications

Host speciesRabbit
Species ReactivityZebrafish
FormatLiquid or Lyophilized
BufferPBS, 50% glycerol
Regulatory StatusFor Research Use Only. Not For Clinical Use.
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use

Application Information

ApplicationWB, IHC, ICC, IF, ELISA

Target

IntroductionThe protein encoded by this gene can heterodimerize with the mismatch repair endonuclease PMS2 to form MutL α, which is part of the DNA mismatch repair system. When MutL alpha binds to MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces single-strand breaks near DNA mismatches, providing entry points for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with the DNA mismatch repair protein MLH3 to form MutL gamma involved in meiosis. This gene was identified as a frequently mutated locus in hereditary nonpolyposis colon cancer (HNPCC). [Provided by RefSeq, August 2017]
Alternative NamesCOCA2FCC2; DNA mismatch repair protein Mlh1; hMLH1; HNPCC; HNPCC2MGC5172; mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2); mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); MutL protein homolog 1 MLH1 COCA2, FCC2, HNPCC, HNPCC2, MMRCS1, hMLH1 mutL homolog 1 DNA mismatch repair protein Mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2
Gene ID4292
UniProt IDP40692
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For Research Use Only | Not For Clinical Use.
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