Mouse Anti-Tomato MLH1 Antibody (MO-AB-34908H)
Cat: MO-AB-34908H
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Tomato (Lycopersicon esculentum) |
| Clone | MO34908C |
| Specificity | This antibody binds to Tomato MLH1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). |
| Product Overview | This product is a mouse antibody against MLH1. It can be used for MLH1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | MLH1 |
| UniProt ID | A5H619 |
| Protein Refseq | The length of the protein is 730 amino acids long. The sequence is show below: MEDEAIPVPIPKEPPKIQRLEECVVNRIAAGEVIQRPVSAVKELIENSLDADSTSISVVVKDGGLKLIQVSDDGHGIRYEDLPILCERYTTSKLSKFEDLQSIRSMGFRGEALASMTYVGHVTVTTITMGQLHGYRATYRDGLMVDEPKACAAVKGTQIMIENLFYNMAARRKTLQNSADDYPKIVDIISRFGIHHTHVSFSCRKHGAGRADVHTIATSSRLDAIRSVYGASVARDLMNIEVSDTGPLISVFKMDGFISNSNYIAKKTTMVLFINDRLIDCGALKRAIEIVYTATLPKASKPFIYMSIILPPEHVDVNIHPTKREVSFLNQEFVIEKIQSVVGSKLRSSNESRTFQEQTMDLSSSGPMGQDSTKESSPSGIKSQKVPHKMVRTDTLDPSGRLHAYMQMKPPGNSERGPCFSSVRSSIRQRRNPSDTADLTSIQELVNEIDNDCHPGLLDIVRNCTYTGMADEIFALLQHNTHLYLVNVINLSKELMYQQVLRRFAHFNAIQLSEPASLPELVMLALKEEGSDPEGNESKELRGKIAEIEYRTAQAKGWNARRSILVFIIDSNGNMSSLPVYWDQYTPDMGPHPRNLLLWFRKILNWGRTKKFGFQDNWLVVLRKIFLPCIPPLLPKSLRGWLEILQKRELSSGSEVTSIDNIENDTTEAEFDEELRLEAENAWAQREWSIQHVLFPSLRLFFKPPTSMVTNGTFVQVASLEKLYRIFERC. |
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For Research Use Only | Not For Clinical Use.
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