Mouse Anti-O. anatinus FEN1 Antibody (MO-AB-06475Y)
Cat: MO-AB-06475Y
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | O. anatinus (Ornithorhynchus anatinus) |
| Clone | MO06475Y |
| Specificity | This antibody binds to O. anatinus FEN1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Mitochondrion |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. |
| Product Overview | This product is a mouse antibody against FEN1. It can be used for FEN1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Flap endonuclease 1; FEN-1; EC 3.1.-.-; Flap structure-specific endonuclease 1; FEN1 |
| UniProt ID | F7EFX2 |
| Protein Refseq | The length of the protein is 387 amino acids long. The sequence is show below: MGIHGLAKLIADVAPGAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMVENGIKPVYVFDGKPPQLKSGELAKRGERRAEAEKQLQRAQDAGAEEDVEKFTKRLVKVTKQHNDECKQLLRLMGIPYLEAPSEAEASCAALKAGKVYAAATEDMDCLTFDSPVLMQHLTASRSLRNDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGELAKRGERRAEAEKQLQRAQDAGAEEDVEKFTKRLVKVTKQHNDECKQLLASWASLPGRAPSEAEXLFMCGEKQFNEDRVRYGVRRLSKSRQGSTQGRLDDFFKVTGCLTSAKRKEPEPKGPTKKRSKTAPAAGGKFKRGK. |
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| MO-DKB-00056W | Rabbit Anti-FEN1 Antibody (MO-DKB-00056W) |
For Research Use Only | Not For Clinical Use.
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