Mouse Anti-O. mykiss Abcb1 Antibody (MO-AB-10588Y)
Cat: MO-AB-10588Y
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | O. mykiss (Oncorhynchus mykiss) |
Clone | MO10588Y |
Specificity | This antibody binds to O. mykiss Abcb1. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Plasma membrane; Other locations |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. |
Product Overview | This product is a mouse antibody against Abcb1. It can be used for Abcb1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
Alternative Names | P-glycoprotein; Abcb1 |
UniProt ID | Q5I1Z1 |
Protein Refseq | The length of the protein is 1162 amino acids long. The sequence is show below: MGKKDEIAVAKVKIEQNGDIGEDKDEEKKGEKEPKMPMIGAIALFRFADGWDRLMIVLGTIMAMVNGTVLPLMCIVFGDMTDSFIGDSIQTQNNFTNITFPVSNTTLGEEMTGHAIYYSIMGAVVLVAAYMQVAFWTLAAGRQVKRLMKLFFHCIMQQEIGWFDVNETGELNTRLTDDIYKINEGIGDKVGMLIQSFTTFVASFIIGFSKGWKLTLVILAVSPVLGFSAFIFSKVLTSFTSLEQSAYAKAGAVAEEVISSVRTVFAFGGQQKEITRYEKNLEDAKNMGIRKATSANIAMGFTFLMIYLSYALSFWYGSTLILSGEYTIGTVLTVFFTVLIGAFAMGQTSPNVQAFASARGAAHKVYNITDNKPHINSYSDHGYKPDVIKGNIEFNNIHFTYPSRPNVKVLNGMSLSVRSGQTIALVGSSGCGKSTTVQLLQRFYDPQDGSVYVDGHDVRSLNVRFLREMIGVVSQEPILFATTIAENIRYGRPDVTHQEIEQAAREANAHDFIMTLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRQGRTTIVVAHRLSTIRNADVIAGFQKGEIVELGTHSQLMEKEGVYHTLVTMQTFKSPEEGEEAVEEQVLEEKSPSVTPFSETTLIRRKSTKGSSFVGSEKGDKDKTEVEEEVFAEQDQELVRQRSSFYSIMFALIGVVSFITMFLQGFCFGKAGEILTMKLRLMAFKAMMRQELGWYDSHKNSVGALTTRLATDAAQVQGATGVRLATLAQNVANLGTSLIISFVYGWQLTLLILCVVPVMAVAGGIQMKMLSGHAVKDKKELEQAGKTATEAIENIRTVASLTREQKFESLYQENLIVPYKNSQKKAHVYGITFSFSQAMIYFAYVGCFRFGAWLIEEGIMTFENVFLVISAVLYGAMAVGEANSFTPNYAKAKISASHLMFLINREPAIDNCSQGGETPDHFDGNVRFQGVRFNYPSRPDLAVLQGLELKVQKGQTLALVGSSGCGKSTTIQLLERFYDPLQGTVMLDNSDAKKLNIHWLRAQMGIVSQEPVLFDCSLAENIAYGDNTRKVTMKEIQSAAKAANIHSFIDDLPQKYDTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESER. |
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For Research Use Only | Not For Clinical Use.
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