Mouse Anti-O. mykiss Abcb1 Antibody (MO-AB-10588Y)


Cat: MO-AB-10588Y
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityO. mykiss (Oncorhynchus mykiss)
CloneMO10588Y
SpecificityThis antibody binds to O. mykiss Abcb1.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationPlasma membrane; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Product OverviewThis product is a mouse antibody against Abcb1. It can be used for Abcb1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative NamesP-glycoprotein; Abcb1
UniProt IDQ5I1Z1
Protein RefseqThe length of the protein is 1162 amino acids long. The sequence is show below: MGKKDEIAVAKVKIEQNGDIGEDKDEEKKGEKEPKMPMIGAIALFRFADGWDRLMIVLGTIMAMVNGTVLPLMCIVFGDMTDSFIGDSIQTQNNFTNITFPVSNTTLGEEMTGHAIYYSIMGAVVLVAAYMQVAFWTLAAGRQVKRLMKLFFHCIMQQEIGWFDVNETGELNTRLTDDIYKINEGIGDKVGMLIQSFTTFVASFIIGFSKGWKLTLVILAVSPVLGFSAFIFSKVLTSFTSLEQSAYAKAGAVAEEVISSVRTVFAFGGQQKEITRYEKNLEDAKNMGIRKATSANIAMGFTFLMIYLSYALSFWYGSTLILSGEYTIGTVLTVFFTVLIGAFAMGQTSPNVQAFASARGAAHKVYNITDNKPHINSYSDHGYKPDVIKGNIEFNNIHFTYPSRPNVKVLNGMSLSVRSGQTIALVGSSGCGKSTTVQLLQRFYDPQDGSVYVDGHDVRSLNVRFLREMIGVVSQEPILFATTIAENIRYGRPDVTHQEIEQAAREANAHDFIMTLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRQGRTTIVVAHRLSTIRNADVIAGFQKGEIVELGTHSQLMEKEGVYHTLVTMQTFKSPEEGEEAVEEQVLEEKSPSVTPFSETTLIRRKSTKGSSFVGSEKGDKDKTEVEEEVFAEQDQELVRQRSSFYSIMFALIGVVSFITMFLQGFCFGKAGEILTMKLRLMAFKAMMRQELGWYDSHKNSVGALTTRLATDAAQVQGATGVRLATLAQNVANLGTSLIISFVYGWQLTLLILCVVPVMAVAGGIQMKMLSGHAVKDKKELEQAGKTATEAIENIRTVASLTREQKFESLYQENLIVPYKNSQKKAHVYGITFSFSQAMIYFAYVGCFRFGAWLIEEGIMTFENVFLVISAVLYGAMAVGEANSFTPNYAKAKISASHLMFLINREPAIDNCSQGGETPDHFDGNVRFQGVRFNYPSRPDLAVLQGLELKVQKGQTLALVGSSGCGKSTTIQLLERFYDPLQGTVMLDNSDAKKLNIHWLRAQMGIVSQEPVLFDCSLAENIAYGDNTRKVTMKEIQSAAKAANIHSFIDDLPQKYDTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESER.
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For Research Use Only | Not For Clinical Use.
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