Mouse Anti-Sheep Parp1 Antibody (MO-AB-17027Y)
Cat: MO-AB-17027Y
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Sheep (Ovis aries) |
| Clone | MO17027Y |
| Specificity | This antibody binds to Sheep Parp1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Participates in the base excision repair (BER) pathway by catalyzing the poly(ADP-ribosylation) of a limited number of receptor proteins involved in chromatin structure and DNA metabolism. This modification follows DNA damage and occurs as a mandatory step in the detection/signaling pathway, leading to the repair of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates poly(ADP-ribosylation) of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. Together with EEF1A1 and TXK, form a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-γ to directly regulate its transcription, thus playing an important role in Th1 cytokine production (PubMed: 17177976). Recruitment of PARP9 and DTX3L to DNA damage sites is required (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80 and BRCA1 to sites of DNA damage (PubMed:23230272). Mediates serine ADP ribosylation of target proteins after interaction with HPF1; HPF1 confers serine specificity (PubMed:28190768). Mediates histone multimerization (ADP-ribosylation) in an HPF1-dependent manner (PubMed:27067600). Involved in ATP synthesis in the nucleus along with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP production is required for energy-intensive chromatin remodeling events (PubMed:27257257). |
| Product Overview | This product is a mouse antibody against Parp1. It can be used for Parp1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Poly(ADP-ribose) synthetase; Parp1 |
| UniProt ID | A9XIV9 |
| Protein Refseq | The length of the protein is 48 amino acids long. The sequence is show below: VKATIEKLGGKLTGTANKASLCISTKKEVDKMNKKMEEVKEANIRVVS. |
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For Research Use Only | Not For Clinical Use.
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