Anti-TNF Antibody (Cat MO-MMB-0670), Mouse IgG1, kappa


Cat: MO-MMB-0670
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityDog (Canis lupus familiaris), Cat (Felis catus), Human (Homo sapiens), Mouse (Mus musculus), Rabbit (Oryctolagus cuniculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
ImmunogenAmino acids 115-130 of human protein are used as the immunogen for this anti-TNFα antibody.
EpitopeN-terminus
FormatLiquid or Lyophilized
BufferPBS, pH 7.4, 0.1 mg/ml BSA
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationProtein G purified

Application Information

ApplicationFC, IF, IHC
Application NotesFC: 0.5-1 µg/million cells in 0.1 mL
IF: 0.5-1 µg/mL
IHC: 2-4 µg/mL
The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Alternative NamesTumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; Cachectin; TNF-Alpha; TNFSF2; TNF-A; TNFA; Tumor Necrosis Factor (TNF Superfamily, Member 2); Tumor Necrosis Factor Ligand 1F
Gene ID7124
UniProt IDP01375
For Research Use Only | Not For Clinical Use.
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