Rabbit Anti-Wnt10a (Center) Antibody (Cat MO-DKB-03351W)


Cat: MO-DKB-03351W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Rabbit (Oryctolagus cuniculus), Mouse (Mus musculus), Rat (Rattus norvegicus), Cattle (Bos taurus), Dog (Canis lupus familiaris), Guinea pig (Cavia porcllus), Zebrafish (Danio rerio)
SpecificityThis antibody is binds to Human Wnt-10a and has cross reactivity with Rabbit, Mouse, Rat, Cattle, Dog, Guinea pig, Zebrafish Wnt-10a.
ImmunogenThe synthetic peptide corresponding to Wnt10a (without wing-related MMTV integration site 10a) The peptide sequence is selected from the middle region of Wnt10a. Peptide sequence RDQRWNCSSLETRNKVPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACA. The peptide sequence of the immunogen was taken from the region.
EpitopeCenter
FormatLiquid or Lyophilized
BufferPBS, 2% Sucrose
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationAffinity purified

Application Information

ApplicationWB, IHC, IHC-P
Application NotesWestern Blot: 1.0 ug/mL
Immunohistochemistry: 1:10-1:500
Immunohistochemistry-Paraffin: 1:10-1:500
The optimal dilution should be determined by the end user.

Target

IntroductionThe WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
Product OverviewThis product is a Rabbit antibody against the Wnt-10a. It can be used for Wnt-10a detection in Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Alternative NamesProtein Wnt; wnt10
UniProt IDB0V1G8
For Research Use Only | Not For Clinical Use.
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