T-cell surface glycoprotein CD3 zeta chain
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
Mouse Anti-Rhesus CD247 Antibody (CBMOAB-38678FYA) (CAT#: CBMOAB-38678FYA)
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- Host species: Mouse
- Species Reactivity: Rhesus (Macaca mulatta)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: CD247
Mouse Anti-Rhesus CD247 Antibody (MO-AB-01557W) (CAT#: MO-AB-01557W)
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- Host species: Mouse
- Species Reactivity: Rhesus (Macaca mulatta)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: T-cell surface glycoprotein CD3 zeta chain isoform 2, CD247
Mouse Anti-Rabbit CD247 Antibody (MO-AB-07520Y) (CAT#: MO-AB-07520Y)
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- Host species: Mouse
- Species Reactivity: Rabbit (Oryctolagus cuniculus)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: T-cell surface glycoprotein CD3 zeta chain, CD247
Mouse Anti-Cattle CD247 Antibody (MO-AB-09801R) (CAT#: MO-AB-09801R)
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- Host species: Mouse
- Species Reactivity: Cattle (Bos taurus)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: CD247 molecule, CD247
Mouse Anti-Sheep CD247 Antibody (MO-AB-14493Y) (CAT#: MO-AB-14493Y)
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- Host species: Mouse
- Species Reactivity: Sheep (Ovis aries)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: T-cell surface glycoprotein CD3 zeta chain, CD247
Mouse Anti-Ferret CD247 Antibody (MO-AB-34515W) (CAT#: MO-AB-34515W)
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- Host species: Mouse
- Species Reactivity: Ferret (Mustela Putorius Furo)
- Application: WB, ELISA
- Protein: Submitted name: CD247 antigen
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: CD247 antigen, CD247
Mouse Anti-Zebrafish cd247 Antibody (CBMOAB-69668FYA) (CAT#: CBMOAB-69668FYA)
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- Host species: Mouse
- Species Reactivity: Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: CD247 antigen, cd24
Mouse Anti-Frog cd247 Antibody (MO-AB-02199H) (CAT#: MO-AB-02199H)
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- Host species: Mouse
- Species Reactivity: Frog (Xenopus laevis)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: CD3Z antigen, zeta polypeptide, TiT3 complex, cd3z-A
Mouse Anti-Rat Cd247 Antibody (MO-AB-24621H) (CAT#: MO-AB-24621H)
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- Host species: Mouse
- Species Reactivity: Rat (Rattus norvegicus)
- Application: WB, ELISA
- Protein: T-cell receptor T3 zeta chain
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: CD3 antigen, zeta polypeptide, isoform CRA_b, Cd247 molecule, Protein Cd247, Cd247, Cd3z
