Cat: CBMOAB-04658HCB
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | MO04658HB |
| Specificity | This antibody binds to C. elegans GPX4. |
| Format | Lyophilized |
| Storage | Store at 4°C: short-term (1-2 weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Extracellular region or secreted |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. |
| Product Overview | Mouse Anti-C. elegans GPX4 (clone MO04658HB) Antibody (CBMOAB-04658HCB) is a mouse antibody against GPX4. It can be used for GPX4 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Glutathione peroxidase; gpx-4 |
| UniProt ID | Q9N2X2 |
| Protein Refseq | The length of the protein is 126 amino acids long. The sequence is show below: MASNSLLTLAVSFTVILFAFCVEVDDTLRWKQCAVTNQSVFDFQIETLKGDYTDLSQYRGKVTLLVNVATFCAYTQQYTDFNPILDKYQKQGLVIAAFPCNQFYLQEPAENHELLNGLTHVRPGNG. |
See other products for " Gpx4 "
| MO-AB-26106H | Mouse Anti-Rat Gpx4 Antibody (MO-AB-26106H) |
| MO-AB-07695W | Mouse Anti-Cat GPX4 Antibody (MO-AB-07695W) |
| MO-AB-26105H | Mouse Anti-Rat Gpx4 Antibody (MO-AB-26105H) |
| MO-AB-18189W | Mouse Anti-Chimpanzee GPX4 Antibody (MO-AB-18189W) |
| MO-AB-04047H | Mouse Anti-Frog gpx4 Antibody (MO-AB-04047H) |
| MO-AB-37382W | Mouse Anti-Goat GPx4 Antibody (MO-AB-37382W) |
| MO-AB-26103H | Mouse Anti-Rat Gpx4 Antibody (MO-AB-26103H) |
| CBMOAB-34191FYC | Mouse Anti-Arabidopsis GPX4 Antibody (CBMOAB-34191FYC) |
| MO-AB-04046H | Mouse Anti-Frog gpx4 Antibody (MO-AB-04046H) |
| MO-NAB-00372W | Rabbit Anti-GPX4 Antibody (AA 30-70) |
For Research Use Only | Not For Clinical Use.