Rabbit Anti-CBL Antibody (MO-DKB-01359W)
Cat: MO-DKB-01359W
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Human (Homo sapiens), Rhesus (Macaca mulatta) |
| Immunogen | Recombinant protein containing sequences in the C-terminal region of human CBL. |
| Epitope | The epitope is in the C-terminal of CBL. |
| Format | Liquid or Lyophilized |
| Buffer | PBS, pH 7, 40% Glycerol |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | Affinity purified |
Application Information
| Application | WB, IF |
| Application Notes | Western Blot 1:500-1:3000 Immunocytochemistry/Immunofluorescence 1:50-1:200 |
Target
| Introduction | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] |
| Product Overview | This product is a Rabbit antibody against the C-terminal of the CBL. It can be used for CBL detection in Western Blot, Immunofluorescence. |
| Alternative Names | Cbl Proto-Oncogene; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence; Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase; Casitas B-Lineage Lymphoma Proto-Oncogene; RING-Type E3 Ubiquitin Transferase CBL; Signal Transduction Protein CBL; RING Finger Protein 55; Proto-Oncogene C-Cbl; Oncogene CBL2; RNF55; |
| Gene ID | 867 |
| UniProt ID | P22681 |
See other products for " CBL "
| CBMOAB-25772FYC | Mouse Anti-Arabidopsis CBL Antibody (CBMOAB-25772FYC) |
| CBMOAB-69164FYA | Mouse Anti-Zebrafish cbl Antibody (CBMOAB-69164FYA) |
| MO-AB-52306W | Mouse Anti-Marmoset CBL Antibody (MO-AB-52306W) |
| MO-AB-12174W | Mouse Anti-Chimpanzee CBL Antibody (MO-AB-12174W) |
| CBMOAB-0315YC | Mouse Anti-E. coli cbl Antibody (CBMOAB-0315YC) |
| MO-AB-00333H | Mouse Anti-Arabidopsis CBL Antibody (MO-AB-00333H) |
| MO-AB-02112H | Mouse Anti-Frog Cbl Antibody (MO-AB-02112H) |
| MO-AB-34246H | Mouse Anti-Tomato cbl Antibody (MO-AB-34246H) |
| MO-NAB-00758W | Mouse Anti-Drosophila Cbl Antibody (Full length) |
| MO-AB-02332W | Mouse Anti-Fruit fly Cbl Antibody (MO-AB-02332W) |
For Research Use Only | Not For Clinical Use.
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