Mouse Anti-Tomato cbl Antibody (MO-AB-34246H)
Cat: MO-AB-34246H
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Tomato (Lycopersicon esculentum) |
| Clone | MO34246C |
| Specificity | This antibody binds to Tomato cbl. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
| Product Overview | This product is a mouse antibody against cbl. It can be used for cbl detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Calcineurin B-like molecule; Calcium sensor calcineurin B-like protein; cbl; SlSOS3 |
| UniProt ID | Q4W3B4 |
| Protein Refseq | The length of the protein is 214 amino acids long. The sequence is show below: MGCFPSKICRFSTPGYEDPTLLAAETAFTVSEVEALYELFKKISSSIIDDGLIHKEEFQLAIFKNQNRRDLFADRIFDLFDFKRNGVIGFGEFVRSLSVFHPNAPVADKIAFAFRLYDLRQTGYIEREELKEMVLALLNESDLILSDDIVEMIVDKTFDEADKKSDGKIDEEEWKEFVSMNPSLLKNMTLPYLKDITLAFPSFVMNSEVEDSEV. |
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For Research Use Only | Not For Clinical Use.
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