Mouse Anti-Chicken MBD2 Antibody (MO-AB-02829Y)
Cat: MO-AB-02829Y
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Chicken (Gallus gallus) |
| Clone | MO02829Y |
| Specificity | This antibody binds to Chicken MBD2. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. |
| Product Overview | This product is a mouse antibody against MBD2. It can be used for MBD2 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Methyl-CpG-binding domain protein 2; MBD2 |
| UniProt ID | Q5EFL0 |
| Protein Refseq | The length of the protein is 257 amino acids long. The sequence is show below: MDKQGRTDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSCFDFRTGKMMPSKLQKNKQRLRNESLHPNKGKPDLNTALPIRQTASIFKQPVTKVTNHPDNKVRSDPQRLADQPRQLFWEKRLRGLSASDVGQEILRAMELPRGLQALGPVPDDVTLLSAVASALHVGSVPVTGQLSSAAEKNPAVWLNSSQPLCRAFVVTDDDIRKQEERVRRVRKKLEEALLAGDPAGSRGQDE. |
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For Research Use Only | Not For Clinical Use.
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