Mouse Anti-Zebrafish mbd2 Antibody (CBMOAB-86157FYA)


Cat: CBMOAB-86157FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityZebrafish (Danio rerio)
CloneMO86157FYA
SpecificityThis antibody binds to Zebrafish mbd2.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Product OverviewMouse Anti-Zebrafish mbd2 Antibody is a mouse antibody against mbd2. It can be used for mbd2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesMbd2 protein; Methyl-CpG binding domain protein 2; Methyl-CpG binding protein 2; mbd
UniProt IDQ7ZTV3
Protein RefseqThe length of the protein is 256 amino acids long.
The sequence is show below: MEKKRTDCPALPPGWKKEEVIRKSGLSAGKSDVYYYSPKGKKFRSKPQLSRYLGNTVDLGCFDFRTGKMMPGKMQKSKQRLRNDNLSQSKGKPDLNTALPIRQTASIFKQPVTKVVNHPNNKVKSDLQRATEQPRQLFWEKRLKGLRSWDVSEEVLRTMDLPTGLQSIGPDSSDETLLSAIASALHMSSAPITGQTSSAAEKNPSIWLNTTQPLCKAFSVTDEHIREQELKVQQARRSLEEALMADGLARAAESTV.
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For Research Use Only | Not For Clinical Use.
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