Mouse Anti-Chimpanzee FADD Antibody (MO-AB-15105W)
Cat: MO-AB-15105W
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Chimpanzee (Pan troglodytes) |
| Clone | MO15105W |
| Specificity | This antibody binds to Chimpanzee FADD. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Plasma membrane; Cytosol; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
| Product Overview | Mouse Anti-Chimpanzee FADD Antibody is a mouse antibody against FADD. It can be used for FADD detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Fas (TNFRSF6)-associated via death domain; FADD |
| UniProt ID | H2Q4B6 |
| Protein Refseq | The length of the protein is 208 amino acids long. The sequence is show below: MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKMERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAARAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRACQMNLVADLVQEVQQARDLQNRSGAVSPMSWNSDASTSEAS. |
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For Research Use Only | Not For Clinical Use.
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