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Rabbit Anti-IDE (C-terminal, clone ms2109-029) Antibody (Cat MO-DKB-03621W)


Cat: MO-DKB-03621W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
Clonems2109-029
SpecificityThis antibody is binds to Human Insulin degrading enzyme and has cross reactivity with Mouse, Rat, Zebrafish Insulin degrading enzyme.
ImmunogenHuman insulin degrading enzyme aa 950 to C-terminal
EpitopeC-terminal
FormatLiquid
BufferTBS, pH 7.4, 1% BSA, 40% Glycerol
StorageStore at -20 °C for 12 months.
PurificationProtein A purified

Application Information

ApplicationWB, IHC-P, IF, IHC
Application NotesWestern Blot: 1:300-1000
Immunohistochemistry-Paraffin 1:200-400
Immunofluorescence/Immunocytochemistry: 1:50-200
The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
Product OverviewThis product is a Rabbit antibody against the Insulin degrading enzyme. It can be used for Insulin degrading enzyme detection in Western Blot, Immunohistochemistry-Paraffin, Immunofluorescence, Immunohistochemistry.
Alternative NamesInsulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulysin; Insulinase; IDE
UniProt IDA4QP10
For Research Use Only | Not For Clinical Use.

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