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Rabbit Anti-IDE Antibody (MO-DKB-01481W)


Cat: MO-DKB-01481W
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Lot Number

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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Bovine (Bos taurus), Dog (Canis lupus familiaris), Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
ImmunogenRecombinant protein containing sequences in the central region of the human IDE.
EpitopeThe epitope is in the Center of IDE.
FormatLiquid
BufferPBS, pH 7, 20% Glycerol, 1% BSA
StorageAliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PurityAffinity purified

Application Information

ApplicationWB, KO
Application NotesWestern Blot 1:500-1:3000

Target

IntroductionThis gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
Product OverviewThis product is a Rabbit antibody against the Center of the IDE. It can be used for IDE detection in Western Blot, Knockout Validated.
Alternative NamesInsulin Degrading Enzyme
Gene ID3416
UniProt IDP14735
For Research Use Only | Not For Clinical Use.

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